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July 7, 2015

Weill Cornell Researchers Develop New Kidney Transplant Rejection Test

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Researchers at Weill Cornell Medical College in Qatar and New York have discovered a new test to detect whether a patients’ immune system is rejecting a transplanted kidney.

The new test, if fully developed, could one day help doctors determine whether a patient is rejecting their new kidney far earlier than the test currently used in hospitals.
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Another advantage is that the newly discovered method uses urine analysis, while the current test involves taking biopsy material directly from the implanted kidney using a syringe, which can cause discomfort and bleeding.

The test is described in a research paper published in the prestigious Journal of the American Society of Nephrology and was conducted by a team of WCMC-Q researchers led by Dr Karsten Suhre, Professor of Physiology and Biophysics, in partnership with colleagues at Weill Cornell Medical College in New York, led by Dr Manikkam Suthanthiran, Stanton Griffis Distinguished Professor of Medicine.

Dr Suhre said: “We are very excited about this discovery because it has the potential to lead to a new test that could be both more effective and less invasive for the patient, though we are at a very early stage at the moment. It is always very exciting to make a discovery that has the potential to lead to a real clinical application that will make healthcare better for patients.”

The study, entitled Urine Metabolite Profiles Predictive of Human Kidney Allograft Status, can be read in full at http://jasn.asnjournals.org/content/early/2015/06/05/ASN.2015010107.abstract

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